These include: Note: For more information about the potential negative effects of Zetia, see the Zetia side effects section above. Short term Zetia side effects include mild fatigue, dizziness, diarrhea, nausea and headache. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. This can cause gallstones (hardened stones in your gallbladder). For this purpose, Zetia may be used alone or with fenofibrate. If you develop serious side effects while taking Zetia, call your doctor right away. If you think youve taken too much of this drug, call your doctor. This is because every persons body responds differently to medications. Tried Zetia again to rule out diet causing stomach issues but got same result. Statins are cholesterol drugs that may be taken with Zetia. Repatha is a prescription drug prescribed to lower LDL cholesterol and certain cardiovascular risks. Zetia is indicated as an adjunct to a low-cholesterol diet for treatment of the following types of hyperlipidemia: For treatment of primary hyperlipidemia, Zetia is indicated to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, and apiloprotein B (ApoB). Grapefruit can prevent the breakdown of these drugs in your body. Some people experience mild side effects with Zetia. 22% in people who used Zetia with fenofibrate, 20% in people who used Zetia with fenofibrate, people who used Zetia with atorvastatin or simvastatin had their LDL levels reduced by an average of 21% to 27% (the percentage varied depending on the dosage used), people who used atorvastatin or simvastatin alone had their LDL levels reduced by an average of 7%, people who used Zetia had their sitosterol levels decreased by an average of 21% and their campstrol levels decreased by an average of 24%, people who used a placebo had their sitosterol levels decreased by an average of 4% and their campstrol levels decreased by an average of 3%, bile acid sequestrants, such as cholestyramine (Prevalite, Questran), colesevelam (Welchol), and colestipol (Colestid), statins, such as atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor), Both Zetia and Lipitor are FDA-approved to treat the following conditions* in adults when used with a. Zetia is also FDA-approved to treat the following conditions when used with a low-cholesterol diet: homozygous sitosterolemia in adults and in children ages 10 years and older. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. Zetia is metabolized in the small intestine and liver. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Zetia and Lipitor are both brand-name drugs. The absence of symptoms doesn't necessarily mean that the cause of POTS is gone as well. Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by lightheadedness or dizziness when standing and a racing heart. Learn about the common, mild, and serious side effects it can cause and how to manage them. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. Each type is described below in more detail. Learn about side effects, dosage, uses, interactions, and more. Less commonly, taking Zetia may lead to serious side effects. Theyre a type of fat found in nuts, vegetable oils, and other plant-based foods. This date is typically 1 year from the date they dispensed the medication. Different interactions can cause different effects. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. If youre breastfeeding or planning to breastfeed while taking Zetia, talk with your doctor about the risks and benefits. If youve noticed memory problems while taking Zetia, talk with your doctor. A malfunctioning ANS is sometimes called 'dysautonomia'. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. Yes, there are a few. For instance, some interactions can interfere with how well a drug works. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). But reviews and complaints about medications, including Zetia, may not be as reliable as other types of consumer reviews. In addition, you may need to watch out for grapefruit. For more information on possible side effects of Zetia, see the Zetia side effects section above. If youre not sure if youll need to get prior authorization for Zetia, contact your insurance company. The phase IV clinical study analyzes which people take Zetia and have Diarrhea. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. Zetia isnt a statin drug. Started Zetia 10mg and within a few hours horrible stomach pains began as well as constant flatulence. As with all medications, the cost of Zetia can vary. Some people witness mild symptoms, some have a big impact on their lives due . Its not known if Zetia is safe to take during pregnancy. It can be taken with or without fenofibrate in adults. For homozygous sitosterolemia, Zetia is FDA-approved to decrease levels of two types of plant sterols: sitosterol and campesterol. zetia. Both drugs are typically taken once each day. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. Zetia contains the active drug ezetimibe. The side effects of Zetia in children are similar to the side effects in adults. Other side effects not listed may also occur in some patients. As with most drugs, some people can have an allergic reaction after taking Zetia. Learn about side effects, costs. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. Increased liver enzyme levels are a possible side effect of Zetia. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Your doctor will also prescribe a low-cholesterol diet for you to follow while taking Zetia. This can cause Zetia to be less effective. Tramadol will usually cause a blistering type rash with itching which you do not describe. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). Zetia may be used with statin drugs or with fenofibrate when used to treat certain conditions. However, if the side effects last longer than . But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. Treatment is targeted at relieving low blood volume or regulating circulatory problems that may cause the disorder. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). Brain fog. Dont take an extra dose to make up for your missed dose. In fact, researchers have looked into using Zetia to treat hair loss due to a condition called alopecia areata. Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. Physicians who treat dysautonomia can be located on our Physician List. In rare cases, taking Zetia with a statin drug may cause rhabdomyolysis (muscle breakdown). Lipitor contains the active drug atorvastatin. If youre concerned about weight gain while using Zetia, talk with your doctor. POTS is a kind of dysautonomia or autonomic nervous disorder. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). Cholesterol is a fatty substance found in the cells of your body. But, they can have side effects and might not be right for you. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. However, be sure to take the dosage your doctor prescribes for you. Zetia may also be used off-label for other conditions. I take pravastatin 80mg with absolutely no problem. If you have any questions about eating certain foods while taking Zetia, talk with your doctor. Zetia is a lipid-lowering compound used to treat high cholesterol.Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection ().. Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema - swelling of the skin and underlying tissues of the head and neck - that can be life-threatening), skin rash . People with HoFH have high levels of LDL (bad) cholesterol. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. And taking it with Zetia and a statin likely wont cause any problems. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. Liver problems. Before taking Zetia, talk with your doctor about your health history. Instead, it belongs to a class of drugs called cholesterol absorption inhibitors. And your doctor can use this information to adjust your treatment plan if needed. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Most of Zetias side effects should go away within a few days or weeks. Healthline Media does not provide medical advice, diagnosis, or treatment. It's Aimee Esther here! Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). Talk with your doctor about birth control options that may be best for you. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). Its primary metabolic pathway is via hepatic glucuronic conjunction. Medications in the statin drug class work differently than cholesterol absorption inhibitors like Zetia. For more information about how the drug is used, see the Zetia uses section below. Stopping Zetia treatment shouldnt cause any noticeable side effects. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. You may not have any symptoms of gallstones unless they cause your gallbladder to swell. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). Lipitor and Zetia belong to different drug classes. If you already have liver problems, taking Zetia may worsen your condition. Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. Theyll guide you with suggestions they may have to relieve these side effects. In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. The generic is considered to be as safe and effective as the original drug. Hot and cold spells. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Ezetimibe may cause side effects. Its called homozygous because the genes that cause this condition are inherited from both parents. In studies, muscle problems commonly occurred in adults and children who took Zetia with statin drugs. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. Memory loss isnt a side effect of Zetia. A generic drug is an exact copy of the active drug in a brand-name medication. Or should I wait to see if I develop such side effects? And do not stop using Zetia unless your doctor recommends it. After stopping Zetia treatment, their liver enzymes levels went back down. Zetia can also be used with statin drugs in adults. Depending on your age or other medical conditions you may have, you may be at higher risk of developing rhabdomyolysis while taking Zetia. Zetia is available in a strength of 10 milligrams (mg). Theyll likely have you stop taking Zetia and any statin drug you may be using. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. You cannot reliably predict how your body will react to a treatment based on someone elses experience. diarrhea. The only FDA-approved dosage of Zetia for children is 10 mg once a day. High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. It can cause mild side effects and, less commonly, serious side effects. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. So stopping Zetia may lead to an increase in your cholesterol levels. If you and your doctor determine that Zetia is safe and effective for you, youll likely take it long term. Lipitor is available in a generic form called atorvastatin. 2005-2023 Healthline Media a Red Ventures Company. They may have suggestions depending on your weight and health goals. For more information, see the How Zetia works section below. * For more information about this side effect, see " Zetia: Side effects explained " below. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). Memory loss isnt a side effect of Zetia. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. In people with POTS, more blood collects in the lower body when standing upright. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zetia. (For information on side effects, see the Zetia side effects section above.). Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Generics tend to cost less than brand-name drugs. The manufacturer of Zetia hasnt given birth control recommendations for males using the drug. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. Temporary excursions of 59F to 86F (15C to 30C) are allowed. Taking Zetia with cholestyramine can decrease the amount of Zetia in your body. The heartbeat increases with a feeling of the heart fluttering. You may also have muscle cramps, spasms, or stiffness. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. This is not a complete list of side effects and others may occur. It only comes in a strength of 10 milligrams (mg). If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. Absorption isnt affected by food. You should always consult your doctor or another healthcare professional before taking any medication. POTS affects the body's ability to pump blood from the legs to the rest of the body while standing. What are the more common side effects of Zetia? If youre concerned about joint pain while using Zetia, talk with your doctor. Porphyria patients are often overly sensitive to sunlight. You may also want to check out the online communities at Bezzy. However, animal studies dont always predict what will happens in humans. You should always consult your doctor or another healthcare professional before taking any medication. What is considered high cholesterol? All rights reserved. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. It can develop suddenly or gradually over time. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. (Fenofibrate is a drug used to lower your triglyceride levels.). It can cause mild side effects and, less commonly, serious side effects. Call your doctor right away if you have serious side effects. Drugs in this class prevent your small intestine from absorbing cholesterol. For information on the effectiveness of Zetia, see the Zetia uses section below. Also tell them about any vitamins, herbs, and supplements you use. A generic drug is an exact copy of the active drug in a brand-name medication. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. diarrhea*. If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. Using Zetia for high cholesterol. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. However, you should still check with your doctor or pharmacist before using any of these products while taking Zetia. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. Learn more about the link. Once diagnosed, many patients face waiting lists as long as two years to get . To learn how Zetia and the other treatments in the study affected peoples levels of HDL (good) cholesterol, triglycerides, non-HDL cholesterol, and Apo B, see the prescribing information. unusual tiredness or weakness. Use of the terms male and female in this article refers to sex assigned at birth. Leqvio is a prescription drug used to lower cholesterol. They may be able to suggest ways to relieve this side effect. A medication timer may be useful, too. Zetia side effects. 6. You can learn more about how we ensure our content is accurate and current by reading our. dark colored urine. Medications in the fibrate drug class are used to treat high cholesterol. Zetia has a well-documented safety profile. These symptoms could be life threatening and require immediate medical care. Its not known if Zetia is safe to take during pregnancy. Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. Symptoms: This section is currently in development. You may find your symptoms are worse in the morning, and they may change from day to day. Youll also need to check your insurance plan, as it may only cover one or the other. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. The actual price youll pay for any of these drugs depends on your insurance plan, your location, and the pharmacy you use. Here are some natural statins that may help keep your cholesterol in a healthy. In clinical studies that lasted an average of 12 weeks, Zetia was compared with a placebo (a treatment with no active drug). Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. Crestor contains the active drug rosuvastatin. Total cholesterol is the overall amount of cholesterol found in your blood. (For more information, see Liver problems in the Warnings for Zetia section above.). The generic form of Zetia costs about the same as the generic form of Crestor. Youll likely take Zetia once a day. Its FDA-approved to treat certain forms of high cholesterol in adults and in children ages 10 years and older. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. 5.8k views Answered >2 years ago. Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. Rhabdomyolysis can also occur with statin drugs, and you may need to take Zetia with a statin. Here are answers to some frequently asked questions about Zetia. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. These can be signs of rhabdomyolysis (muscle breakdown), which is a serious medical condition. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. If your doctor has prescribed Zetia and youre interested in using ezetimibe instead, talk with your doctor. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. Zetia is contraindicated under the following conditions: Zetia tablets should be stored at a room temperature of 77F (25C) in a tightly sealed container away from light. Currently, no medications have been approved by the FDA to treat POTS. What causes POTS? Doing this can raise your risk of side effects. Statin drugs arent safe to use during pregnancy. Zetia generally costs less than Lipitor. * To learn more about this side effect, see the Side effects explained section below. Specific statins that were studied included atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), and lovastatin. The brand name for this drug combination is Vytorin. Taking Zetia with a statin drug may increase your risk of developing some mild or serious side effects. Can diet help improve depression symptoms? Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. If your doctor recommends that you stop taking Zetia, they may suggest another treatment option for your condition. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. You can take Zetia with or without food. However, your cholesterol levels may increase if you stop taking the drug. It also helps keep the drug from harming the environment. It belongs to a class of drugs called cholesterol absorption inhibitors. Your doctor may prescribe Zetia with a statin drug. To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). Ways to reduce the symptoms. Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). The dosage is the same for all approved uses. Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. They often originate at the base of the skull and spreading on the back of the head and neck. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Zetia and Crestor have some similar side effects and others that differ. Zetia is primarily cleared from the body through fecal excretion. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Few days or weeks other conditions tablets can be located on our Physician.... It intervenes in human lives for corporate profit to watch out for grapefruit different treatment option for your condition t. Your doctor may have, you should continue using it other side effects include mild fatigue, dizziness,,... Be signs of rhabdomyolysis ( muscle breakdown ) of fats called plant sterols in people with POTS, more collects. Are severe, call your doctor about birth control recommendations for males using the drug from the. Be sure to take the dosage is the same as the what causes pots zetia.! 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